hrp0082lbp-d3-1014 | (1) | ESPE2014

CpG Methylation Changes within the INS, HLA-G and PTPN-22 Promoters in Childhood Type 1 Diabetes

Kyrgios Ioannis , Mouzaki Konstantina , Spandonidis Theodoros , Fragou Aikaterini , Tzimagiorgis Georgios , Eboriadou-Petikopoulou Maria , Galli-Tsinopoulou Assimina

Background: Alterations in DNA methylation status of specific genetic loci may affect gene expression, thus leading to autoimmunopathies.Objective and hypotheses: This study aimed to investigate possible differences in DNA methylation pattern between type 1 diabetes mellitus (T1DM) youngsters and healthy controls.Method: Ten T1DM participants and 10 age-/gender-matched controls were enrolled. DNA was extracted from white blood cell...